Lopo hurt his right calf in Sunday's 4-0 defeat at Valencia, while Duscher damaged his right thigh during a friendly last week.

The two players' absence adds to Deportivo's problems. The team has dropped to 13th place in the 20-team Spanish league after drawing three and losing four of its seven games since Oct. 22.

Lopo won his first international call-up for Spain's friendly with Romania last month but didn't play in the 1-0 defeat.

Duscher has struggled to make the first team this season and reaches the end of his contract in June. The Argentine international has been linked to a possible move to Manchester United.