Kevin Jones, Detroit's leading rusher and second-leading receiver, was inactive for the Thanksgiving Day game between the Lions and Miami Dolphins.
Jones sprained his ankle in Sunday's loss at Arizona. He was replaced by Arlen Harris.
Detroit was also without defensive tackle Shaun Rogers (knee), kick returner Eddie Drummond (concussion) and defensive tackle Shaun Cody (toe).
Little-used wide receiver Mike Williams, Detroit's first-round pick in 2005, was active. Williams has not caught a pass this season.
Miami cornerback Will Allen was inactive with a groin injury and was replaced in the starting lineup by Travis Daniels.
